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Electrochemical biosensing based on protein-directed carbon nanospheres embedded with SnO and TiO nanocrystals for sensitive detection of tobramycin.

Wang, Minghua; Hu, Bin; Yang, Chuang; Zhang, Zhihong; He, Linghao; Fang, Shaoming; Qu, Xiongwei; Zhang, Qingxin.
Biosens Bioelectron; 99: 176-185, 2018 Jan 15.
Article in En | MEDLINE | ID: mdl-28756323


A series of nanocomposites comprised of homogeneous mesoporous carbon nanospheres embedded with SnO (x = 0, 1, or 2) and TiO nanocrystals using bovine serum albumin (BSA) as template followed by calcinated at different temperatures (300, 500, 700, and 900°C) were prepared, and were denoted as SnO @TiO @mC. Then a novel electrochemical biosensing strategy for detecting tobramycin (TOB) based on the nanocomposites was constructed. The as-prepared SnO @TiO @mC nanocomposites not only possess high specific surface area and good electrochemical activity but also exhibit strong bioaffinity with the aptamer strands, therefore, they were applied as the scaffold for anchoring TOB-targeted aptamer and further used to sensitively detect trace TOB in aqueous solutions. By comparing the electrochemical biosensing responses toward TOB detection based on the four SnO @TiO @mC nanocomposites, the biosensing system constructed with SnO @TiO @mC (derived at 900°C) demonstrated the highest determination efficiency, high selectivity, and good stability. In particular, the new proposed aptasensing method based on SnO @TiO @mC nanocomposite exhibits considerable potential for the quantitative detection of TOB in the biomedical field.